Entangling macroscopic diamonds at room temperature: Bounds on the continuous-spontaneous-localization parameters

A recent experiment [K. C. Lee et al., Science 334, 1253 (2011)] succeeded in detecting entanglement between two macroscopic specks of diamonds, separated by a macroscopic distance, at room temperature. This impressive results is a further confirmation of the validity of quantum theory in (at least parts of) the mesoscopic and macroscopic domain, and poses a challenge to collapse models, which predict a violation of the quantum superposition principle, which is the bigger the larger the system. We analyze the experiment in the light of such models. We will show that the bounds placed by experimental data are weaker than those coming from matter-wave interferometry and non-interferometric tests of collapse models.Comment: 7 pages, 3 figures, v2: close to the published version, LaTe

Examining the efficacy of a genotyping-by-sequencing technique for population genetic analysis of the mushroom Laccaria bicolor and evaluating whether a reference genome is necessary to assess homology

Given the diversity and ecological importance of Fungi, there is a lack of population genetic research on these organisms. The reason for this can be explained in part by their cryptic nature and difficulty in identifying genets. In addition the difficulty (relative to plants and animals) in developing molecular markers for fungal population genetics contributes to the lack of research in this area. This study examines the ability of restriction-site associated DNA (RAD) sequencing to generate SNPs in Laccaria bicolor. Eighteen samples of morphologically identified L. bicolor from the United States and Europe were selected for this project. The RAD sequencing method produced anywhere from 290 000 to more than 3 000 000 reads. Mapping these reads to the genome of L. bicolor resulted in 84 000-940 000 unique reads from individual samples. Results indicate that incorporation of non-L. bicolor taxa into the analysis resulted in a precipitous drop in shared loci among samples, suggests the potential of these methods to identify cryptic species. F-statistics were easily calculated, although an observable "noise" was detected when using the "All Loci" treatment versus filtering loci to those present in at least 50% of the individuals. The data were analyzed with tests of Hardy-Weinburg equilibrium, population genetic statistics (FIS and FST), and population structure analysis using the program Structure. The results provide encouraging feedback regarding the potential utility of these methods and their data for population genetic analysis. We were unable to draw conclusions of life history of L. bicolor populations from this dataset, given the small sample size. The results of this study indicate the potential of these methods to address population genetics and general life history questions in the Agaricales. Further research is necessary to explore the specific application of these methods in the Agaricales or other fungal groups

Concordant cues in faces and voices: testing the backup signal hypothesis

Information from faces and voices combines to provide multimodal signals about a person. Faces and voices may offer redundant, overlapping (backup signals), or complementary information (multiple messages). This article reports two experiments which investigated the extent to which faces and voices deliver concordant information about dimensions of fitness and quality. In Experiment 1, participants rated faces and voices on scales for masculinity/femininity, age, health, height, and weight. The results showed that people make similar judgments from faces and voices, with particularly strong correlations for masculinity/femininity, health, and height. If, as these results suggest, faces and voices constitute backup signals for various dimensions, it is hypothetically possible that people would be able to accurately match novel faces and voices for identity. However, previous investigations into novel face–voice matching offer contradictory results. In Experiment 2, participants saw a face and heard a voice and were required to decide whether the face and voice belonged to the same person. Matching accuracy was significantly above chance level, suggesting that judgments made independently from faces and voices are sufficiently similar that people can match the two. Both sets of results were analyzed using multilevel modeling and are interpreted as being consistent with the backup signal hypothesis

15-An Archaeological Survey in Pavilion and Schoolcraft Townships, Kalamazoo County, Michigan

During the 1984 field season, Dr. William Cremin and the Western Michigan University archaeological field school continued the program of site location survey that had been initiated two years earlier in Pavilion Township (T3S RlOW), Kalamazoo County, Michigan. In addition, a small area flanking the north end of Barton Lake in nearby Schoolcraft Township (T4S RllW) was similarly evaluated. With the cooperation of numerous area landowners and local artifact collectors, almost 40 parcels of land aggregating 361 ha in Pavilion and 33 ha in Schoolcraft townships were surveyed by means of surface reconnaissance procedures. There follows a report of our survey activity, including descriptions of the archaeological sites that were recorded and collected and recommendations regarding the proper disposition of several \u27\u27problem\u27\u27 sites; the latter reflect in one instance disagreement among the documentary sources as to the location of a burial mound and in a second the erroneous recording of a natural feature on the landscape as a cultural phenomenon (i.e. burial mound)

Testing the assumptions of linear prediction analysis in normal vowels

This paper develops an improved surrogate data test to show experimental evidence, for all the simple vowels of US English, for both male and female speakers, that Gaussian linear prediction analysis, a ubiquitous technique in current speech technologies, cannot be used to extract all the dynamical structure of real speech time series. The test provides robust evidence undermining the validity of these linear techniques, supporting the assumptions of either dynamical nonlinearity and/or non-Gaussianity common to more recent, complex, efforts at dynamical modelling speech time series. However, an additional finding is that the classical assumptions cannot be ruled out entirely, and plausible evidence is given to explain the success of the linear Gaussian theory as a weak approximation to the true, nonlinear/non-Gaussian dynamics. This supports the use of appropriate hybrid linear/nonlinear/non-Gaussian modelling. With a calibrated calculation of statistic and particular choice of experimental protocol, some of the known systematic problems of the method of surrogate data testing are circumvented to obtain results to support the conclusions to a high level of significance

Statistical properties of linear prediction analysis underlying the challenge of formant bandwidth estimation

Formant bandwidth estimation is often observed to be more challenging than the estimation of formant center frequencies due to the presence of multiple glottal pulses within a period and short closed-phase durations. This study explores inherently different statistical properties between linear prediction (LP)–based estimates of formant frequencies and their corresponding bandwidths that may be explained in part by the statistical bounds on the variances of estimated LP coefficients. A theoretical analysis of the Cramér-Rao bounds on LP estimator variance indicates that the accuracy of bandwidth estimation is approximately twice as low as that of center frequency estimation. Monte Carlo simulations of all-pole vowels with stochastic and mixed-source excitation demonstrate that the distributions of estimated LP coefficients exhibit expectedly different variances for each coefficient. Transforming the LP coefficients to formant parameters results in variances of bandwidth estimates being typically larger than the variances of respective center frequency estimates, depending on vowel type and fundamental frequency. These results provide additional evidence underlying the challenge of formant bandwidth estimation due to inherent statistical properties of LP-based speech analysi

Implementing Pharmacy Informatics in College Curricula: The AACP Technology in Pharmacy Education and Learning Special Interest Group

Many professional organizations have initiatives to increase the awareness and use of informatics in the practice of pharmacy. Within education we must respond to these initiatives and make technology integral to all aspects of the curriculum, inculcating in students the importance of technology in practice. This document proposes 5 central domains for organizing planning related to informatics and technology within pharmacy education. The document is intended to encourage discussion of informatics within pharmacy education and the implications of informatics in future pharmacy practice, and to guide colleges of pharmacy in identifying and analyzing informatics topics to be taught and methods of instruction to be used within the doctor of pharmacy curriculum

The role of envelope periodicity in the perception of masked speech with simulated and real cochlear implants

In normal hearing, complex tones with pitch-related periodic envelope modulations are far less effective maskers of speech than aperiodic noise. Here, it is shown that this masker-periodicity benefit is diminished in noise-vocoder simulations of cochlear implants (CIs) and further reduced with real CIs. Nevertheless, both listener groups still benefitted significantly from masker periodicity, despite the lack of salient spectral pitch cues. The main reason for the smaller effect observed in CI users is thought to be an even stronger channel interaction than in the CI simulations, which smears out the random envelope modulations that are characteristic for aperiodic sounds. In contrast, neither interferers that were amplitude-modulated at a rate of 10 Hz nor maskers with envelopes specifically designed to reveal the target speech enabled a masking release in CI users. Hence, even at the high signal-to-noise ratios at which they were tested, CI users can still exploit pitch cues transmitted by the temporal envelope of a non-speech masker, whereas slow amplitude modulations of the masker envelope are no longer helpful

Developing Organ Offer and Acceptance Measures: When ‘Good’ Organs Are Turned Down

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75521/1/j.1600-6143.2007.01784.x.pd

Neurological Disease Detection and Monitoring from Voice Production

The dramatic impact of neurological degenerative pathologies in life quality is a growing concern. It is well known that many neurological diseases leave a fingerprint in voice and speech production. Many techniques have been designed for the detection, diagnose and monitoring the neurological disease. Most of them are costly or difficult to extend to primary attention medical services. Through the present paper it will be shown how some neurological diseases can be traced at the level of phonation. The detection procedure would be based on a simple voice test. The availability of advanced tools and methodologies to monitor the organic pathology of voice would facilitate the implantation of these tests. The paper hypothesizes that some of the underlying mechanisms affecting the production of voice produce measurable correlates in vocal fold biomechanics. A general description of the methodological foundations for the voice analysis system which can estimate correlates to the neurological disease is shown. Some study cases will be presented to illustrate the possibilities of the methodology to monitor neurological diseases by voic